From SARS to MERS: evidence and speculation
Identifieur interne : 001244 ( Main/Exploration ); précédent : 001243; suivant : 001245From SARS to MERS: evidence and speculation
Auteurs : Hainv Gao [République populaire de Chine] ; Hangping Yao [République populaire de Chine] ; Shigui Yang [République populaire de Chine] ; Lanjuan Li [République populaire de Chine]Source :
- Frontiers of Medicine [ 2095-0217 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (usage thérapeutique), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Facteurs de risque, Flambées de maladies, Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (transmission), Infections à coronavirus (épidémiologie), Syndrome respiratoire aigu sévère (épidémiologie), Zoonoses (virologie), Zoonoses (épidémiologie).
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus.
- usage thérapeutique : Antiviraux, Infections à coronavirus.
- virologie : Zoonoses.
- épidémiologie : Infections à coronavirus, Syndrome respiratoire aigu sévère, Zoonoses.
- Animaux, Facteurs de risque, Flambées de maladies, Humains.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (therapeutic use), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Coronavirus Infections (transmission), Disease Outbreaks, Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Risk Factors, Severe Acute Respiratory Syndrome (epidemiology), Zoonoses (epidemiology), Zoonoses (virology).
- MESH :
- chemical , therapeutic use : Antiviral Agents.
- drug therapy : Coronavirus Infections.
- epidemiology : Coronavirus Infections, Severe Acute Respiratory Syndrome, Zoonoses.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- transmission : Coronavirus Infections.
- virology : Zoonoses.
- Animals, Disease Outbreaks, Humans, Risk Factors.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic pathogen. In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has spread to more than 1600 patients in 26 countries, resulting in over 600 deaths.Without a travel history, few clinical and radiological features can reliably differentiate MERS from SARS. But in real world, comparing with SARS, MERS presents more vaguely defined epidemiology, more severe symptoms, and higher case fatality rate. In this review, we summarize the recent findings in the field of MERS-CoV, especially its molecular virology, interspecies mechanisms, clinical features, antiviral therapies, and the further investigation into this disease. As a newly emerging virus, many questions are not fully answered, including the exact mode of transmission chain, geographical distribution, and animal origins. Furthermore, a new protocol needs to be launched to rapidly evaluate the effects of unproven antiviral drugs and vaccine to fasten the clinical application of new drugs.
Url:
DOI: 10.1007/s11684-016-0466-7
PubMed: 27726088
PubMed Central: 7088694
Affiliations:
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Le document en format XML
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when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (therapeutic use)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (transmission)</term><term>Disease Outbreaks</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Risk Factors</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Zoonoses (epidemiology)</term><term>Zoonoses (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (usage thérapeutique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Facteurs de risque</term><term>Flambées de maladies</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (transmission)</term><term>Infections à coronavirus (épidémiologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Zoonoses (virologie)</term><term>Zoonoses (épidémiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term><term>Zoonoses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Outbreaks</term><term>Humans</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs de risque</term><term>Flambées de maladies</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic pathogen. In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has spread to more than 1600 patients in 26 countries, resulting in over 600 deaths.Without a travel history, few clinical and radiological features can reliably differentiate MERS from SARS. But in real world, comparing with SARS, MERS presents more vaguely defined epidemiology, more severe symptoms, and higher case fatality rate. In this review, we summarize the recent findings in the field of MERS-CoV, especially its molecular virology, interspecies mechanisms, clinical features, antiviral therapies, and the further investigation into this disease. As a newly emerging virus, many questions are not fully answered, including the exact mode of transmission chain, geographical distribution, and animal origins. Furthermore, a new protocol needs to be launched to rapidly evaluate the effects of unproven antiviral drugs and vaccine to fasten the clinical application of new drugs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zumla, A H D" uniqKey="Zumla A">A H D Zumla</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S 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Chine"><noRegion><name sortKey="Gao, Hainv" sort="Gao, Hainv" uniqKey="Gao H" first="Hainv" last="Gao">Hainv Gao</name></noRegion><name sortKey="Gao, Hainv" sort="Gao, Hainv" uniqKey="Gao H" first="Hainv" last="Gao">Hainv Gao</name><name sortKey="Li, Lanjuan" sort="Li, Lanjuan" uniqKey="Li L" first="Lanjuan" last="Li">Lanjuan Li</name><name sortKey="Li, Lanjuan" sort="Li, Lanjuan" uniqKey="Li L" first="Lanjuan" last="Li">Lanjuan Li</name><name sortKey="Yang, Shigui" sort="Yang, Shigui" uniqKey="Yang S" first="Shigui" last="Yang">Shigui Yang</name><name sortKey="Yang, Shigui" sort="Yang, Shigui" uniqKey="Yang S" first="Shigui" last="Yang">Shigui Yang</name><name sortKey="Yao, Hangping" sort="Yao, Hangping" uniqKey="Yao H" first="Hangping" last="Yao">Hangping Yao</name><name sortKey="Yao, Hangping" sort="Yao, Hangping" uniqKey="Yao H" first="Hangping" last="Yao">Hangping Yao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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